Publications by authors named "L T Hiraki"
Article Synopsis
- Systemic lupus erythematosus (SLE) is a serious autoimmune disease that primarily affects younger patients and those of non-European descent, although the exact causes are still not fully understood.
- Recent research highlights how both common and rare gene variants, along with environmental and epigenetic factors, influence how SLE manifests and its severity, with a notable impact on younger patients.
- Understanding these genetic and epigenetic variations could lead to better diagnostic and treatment strategies tailored to individuals based on their specific risk factors and disease profiles.
Severe Inflammatory Heart Disease in Children With Lupus: A Case Series.
CJC Pediatr Congenit Heart Dis
August 2024
Article Synopsis
- Adolescents with childhood-onset systemic lupus erythematosus (cSLE) experience high rates of mental health (MH) issues, but screening rates for these problems were only 15% at a pediatric clinic before an improvement initiative began.
- The aim was to increase screening for depression and anxiety among cSLE patients aged 12-18 from 15% to 80% by implementing a structured screening workflow and providing training for healthcare providers.
- Over 21 months, screening rates improved significantly, peaking at 100%, with 45% of screened individuals showing symptoms of anxiety and/or depression, leading to increased patient satisfaction and referrals to mental health services.
Article Synopsis
- Some experts and patients worked together to create a set of important data to help study childhood lupus, a disease that affects children.
- They made two datasets: a Core Dataset with 46 necessary items and an Expanded Dataset with 26 extra items, to help gather more information.
- This new information will help researchers around the world study childhood lupus better by using the same important facts and details.
Article Synopsis
- The study looked at people who had a specific type of antibodies (ANAs) but didn’t show any symptoms, to see if they would develop a serious disease called systemic autoimmune rheumatic disease (SARD).
- Out of 207 people, only 23 developed SARD over two years, which means most didn’t get sick.
- When they did get sick, the majority had a condition called systemic lupus erythematosus (SLE), but it seemed to be mild for most of them. They found a better way to identify those who would develop SLE by using new criteria.