CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis.

Early diagnosis is critical for providing a timely window for effective therapy in pulmonary fibrosis (PF); however, achieving this remains a significant challenge. The distinct honeycombing patterns observed in computed tomography (CT) for the primary diagnosis of PF are typically only visible in patients with moderate to severe disease, often leading to missed opportunities for early intervention. In this study, we developed a nanoprobe designed to accumulate at fibroblastic foci and loaded with the CT sensitizer iodide to enable effective early diagnosis of PF.

A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation.

Colorectal cancer (CRC), one of the diseases posing a threat to global health, according to the latest data, is the third most common cancer globally and the second leading cause of cancer-related deaths. The development and refinement of novel structures of small molecular compounds play a crucial role in tumor treatment and overcoming drug resistance. In this study, our objective was to screen and characterize novel compounds for overcoming drug resistance via the B Lymphoma Mo-MLV insertion region 1 (Bmi-1) reporter screen assay.

Pectins play a central role in enhancing Al tolerance of alfalfa via looseing fibre-microfiber arrangement of cell wall in root tips.

Cell wall greatly affects Al tolerance of plants, but the precise mechanisms by which the cell wall modulating Al tolerance remains largely unknown. In the present study, Al tolerant alfalfa varieties (WL525 and WL903) accumulated less Al in root tips, cell wall and pectins, averagely decreased by 23.8 %, 41.

Nitric oxide mitigates cadmium stress by promoting the biosynthesis of cell walls in Robinia pseudoacacia roots.

Cadmium (Cd) pollution is a growing concern worldwide, because it threatens human health through the food chain. Woody plants, such as the pioneer species black locust (Robinia pseudoacacia L.), are widely used in phytoremediation of Cd-contaminated soils, but strongly differ in Cd tolerance.

Modulation of Electrochemical Reactions through External Stimuli: Applications in Oxygen Evolution Reaction and Beyond.

Electrochemical water splitting is a promising method for generating green hydrogen gas, offering a sustainable approach to addressing global energy challenges. However, the sluggish kinetics of the anodic oxygen evolution reaction (OER) poses a great obstacle to its practical application. Recently, increasing attention has been focused on introducing various external stimuli to modify the OER process.