Deep orbital puncture of the superior ophthalmic vein for embolization of indirect carotid-cavernous fistula: a case report, technical note and review of the current literature.

Purpose: Carotid-cavernous fistulas (CCFs) are abnormal connections between the carotid artery and cavernous sinus, often causing ocular symptoms like chemosis, proptosis, and diplopia. Endovascular embolization is the preferred treatment, typically performed via the transfemoral transvenous route through the inferior petrosal sinus (IPS). However, we present a case and a systematic review of indirect CCF treated through deep orbital puncture of the superior ophthalmic vein (SOV) for embolization.

Green Environments and Healthy Aging: Analyzing the Role of Green Infrastructure in the Functional Well-Being of Seniors-A Pilot Study.

Health professionals have slowly integrated the environment and green areas into their prescriptions to connect patients with nature and outdoor activities. The World Health Organization recommends that everyone reside within 300 m of green regions to improve well-being and physical and mental health. The study aimed to explore the effects of urban and rural green areas on multiple physiological and functional variables, as well as evaluate the perception of individuals regarding the ease of use of these same spaces.

Abortion-related complications in Brazil: results from the World Health Organization Multi-country Survey on Abortion (MCS-A).

This study aimed to describe the severity of abortion-related complications, factors associated with complications, the types of management and the experience of care in Brazil. A cross-sectional study in twenty hospitals (10 in Federal District, 3 in Rondônia and 7 in Maranhão). For 3 months, all women treated for abortion/miscarriage had their data collected.

Pharmacodynamic characterization and evaluation of oxidative stress effects of digitoxigenin derivatives on HeLa cells.

Cancer is a leading cause of death worldwide and its treatment is hampered by the lack of specificity and side effects of current drugs. Cardiotonic steroids (CTS) interact with Na/K-ATPase (NKA) and induce antineoplastic effects, but their narrow therapeutic window is key limiting factor. The synthesis of digitoxigenin derivatives with glycosidic unit modifications is a promising approach to develop more selective and effective antitumor agents.

Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex.

Words represent a uniquely human information channel-humans use words to express thoughts and feelings and to assign emotional valence to experience. Work from model organisms suggests that valence assignments are carried out in part by the neuromodulators dopamine, serotonin, and norepinephrine. Here, we ask whether valence signaling by these neuromodulators extends to word semantics in humans by measuring sub-second neuromodulator dynamics in the thalamus (N = 13) and anterior cingulate cortex (N = 6) of individuals evaluating positive, negative, and neutrally valenced words.