Publications by authors named "L Szulc-Dabrowska"
Article Synopsis
- - The discontinuation of the smallpox vaccine in 1980 has led to increased cases of poxvirus infections like monkeypox, raising public health concerns due to lack of immunity in the population.
- - This study uses the ectromelia virus (ECTV), responsible for mousepox, as a model to explore poxvirus behavior and the role of mitochondria in immune response during ECTV infection.
- - Results show that altering the shape of the mitochondrial network affects MAVS-dependent immunity, with elongated networks reducing ECTV replication and fragmented networks leading to increased immune response suppression during infection.
Ectromelia virus (ECTV) is a causative agent of mousepox. It provides a suitable model for studying the immunobiology of orthopoxviruses, including their interaction with the host cell cytoskeleton. As professional antigen-presenting cells, dendritic cells (DCs) control the pericellular environment, capture antigens, and present them to T lymphocytes after migration to secondary lymphoid organs.
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- * In the context of ectromelia virus infection, the effectiveness of cDCs in polarizing T cells can determine whether mouse strains resist or succumb to the viral infection, with Th1 responses being protective and Th2 responses being more detrimental.
- * The study found that even though cDCs in susceptible BALB/c mice showed higher maturation, they produced lower levels of Th1-polarizing cytokines compared to those in resistant C57BL/6 mice, leading to compromised T cell activation in the former. *
Novel Gluconobacter oxydans strains selected from Kombucha with potential postbiotic activity.
Appl Microbiol Biotechnol
December 2024
Gastric and colorectal cancer are among the most frequently diagnosed malignancies of the gastrointestinal tract. Searching for methods of therapy that complements treatment or has a preventive effect is desirable. Bacterial metabolites safe for human health, which have postbiotic effect, are of interest recently.
View Article and Find Full Text PDFThe eradication of smallpox was an enormous achievement due to the global vaccination program launched by World Health Organization. The cessation of the vaccination program led to steadily declining herd immunity against smallpox, causing a health emergency of global concern. The smallpox vaccines induced strong, humoral, and cell-mediated immune responses, protecting for decades after immunization, not only against smallpox but also against other zoonotic orthopoxviruses that now represent a significant threat to public health.
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