Publications by authors named "L Szoka"
, a species native to China, Korea, Japan, and Russia, has been used medicinally in the countries of its origin. Though mono- and sesquiterpenoids are known constituents of , the complete analysis of essential oils produced by the roots and aerial parts of the plant has not been published until now. The present study discloses considerable differences in the composition and cytotoxic activity of essential oils distilled from roots and shoots of .
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- Despite progress in melanoma treatment, it remains highly lethal and natural compounds, especially triterpenes from birch bark, are being explored for their therapeutic potential.
- The study focused on a specific compound called 3,4--dammara-4(29),20(21),24(25)-trien-3-oic acid (SDT) isolated from silver birch buds, which was found to induce cell death in melanoma through both apoptosis (programmed cell death) and autophagy (cellular digestion).
- Results showed that SDT reduced melanoma cell viability in a dose- and time-dependent manner, confirming its potential as a natural anti-melanoma agent by activating key pathways involved in cell death.
Skin cancers are a dominant type of cancer that impacts millions per year. Cancer is a heterogeneous disease triggered by the irreversible impairment of cellular homeostasis and function. In this study, we investigated the activity of 37 structurally diverse flavonoids to find potentially active substances using two melanoma cell lines: C32 and A375.
View Article and Find Full Text PDFIntegrins play a fundamental role in the migration and invasiveness of glioblastoma (GBM) cells, making them suitable targets for innovative cancer therapy. The aim of this study was to evaluate the effect of the RGD homodimeric disintegrin VLO4, isolated from venom, on the adhesion, spreading, migration, and survival of LBC3, LN18, and LN229 cell lines. This disintegrin, as a potent antagonist for α5β1 integrin, showed pro-adhesive properties for these cell lines, the highest for LN229 and the lowest for LBC3.
View Article and Find Full Text PDFCancer of the corpus uteri and cervix uteri, collectively ranks second among new cancer cases in women after breast cancer. Therefore, investigation of new anticancer agents and identifying new molecular targets presents a challenge to improve effectiveness of chemotherapy. In this study, antiproliferative activity of flavonoids derived from the buds of silver birch and downy birch was evaluated in endometrial cancer Ishikawa cells and cervical cancer HeLa cells.
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