Publications by authors named "L Swan"
Lysosomal pH dysregulation is a critical element of the pathophysiology of neurodegenerative diseases, cancers, and lysosomal storage disorders (LSDs). To study the role of lysosomes in pathophysiology, probes to analyze lysosomal size, positioning, and pH are indispensable tools. Here, we developed and characterized a ratiometric genetically encoded lysosomal pH probe, RpH-ILV, targeted to a subpopulation of lysosomal intraluminal vesicles.
View Article and Find Full Text PDFBackground And Objectives: Older people with cognitive impairment are unrepresented in clinical research. Our objective was to review evidence for strategies to support their research inclusion and participation.
Research Design And Methods: Systematic review of published reports of inclusion and participation strategies for older people with cognitive impairment in clinical research (PROSPERO CRD42020212092).
As health care outcomes improve the priority for those living with adult congenital heart disease have changed to a more holistic focus on quality of life and well-being. Although health care has embraced this, there are still areas where there is a deficit in advice, allyship, and advocacy. One of these deficits is in the area of sexual health and well-being.
View Article and Find Full Text PDFHealthcare Provider-Based Contraceptive Coercion: Understanding U.S. Patient Experiences and Describing Implications for Measurement.
Int J Environ Res Public Health
June 2024
Despite growing concerns over coercion in contraceptive care, few studies have described its frequency and manifestations. Further, there is no established quantitative method of measuring this construct. We begin to fill this gap by detailing nuance in contraceptive coercion experiences and testing a novel measure: the Coercion in Contraceptive Care Checklist.
View Article and Find Full Text PDFPopulation modeling analyses of crizotinib in pediatric patients with ALK-positive advanced cancers.
Pediatr Blood Cancer
September 2024
Article Synopsis
- Alterations in the ALK gene are crucial for the development of anaplastic large cell lymphoma (ALCL), and crizotinib is an approved treatment for pediatric patients with this type of cancer.
- The study included data from pediatric patients treated with crizotinib, focusing on how the drug is processed in the body and its safety and effectiveness at different doses.
- Results showed that crizotinib dosing appropriately adjusted for patient size led to similar drug exposure across different ages and tumor types, with a notable relationship between higher doses and better treatment responses, except for severe cases of neutropenia.