How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study.

Objective: The United States faces an opioid crisis. Integrating prescription drug monitoring programs into electronic health records offers promise to improve opioid prescribing practices. This study aimed to evaluate 2 different user interface designs for prescription drug monitoring program and electronic health record integration.

Temperature and pH dependence of fluocinolone acetonide degradation in a topical cream formulation.

We investigated the degradation of fluocinolone acetonide (FA) incorporated into an oil-in-water cream base. The study examined the influence of temperature (23 to 80 degrees C) and cream pH (pH 2.3 to 6) on FA degradation rates.

Extreme vertexes design in formulation development: solubility of butoconazole nitrate in a multicomponent system.

The extreme vertexes design was shown to be an efficient method for the study of mixture problems, for generating points in the factor space that define a region for response surface analysis. By using this method, the solubility of butoconazole nitrate, an imidazole antifungal agent, was studied as a function of four components, polyethylene glycol 400, glycerin, polysorbate 60, and water, whose levels were subject to given constraints. A fifth component, poloxamer 407, was held constant.