evaluation of bioactivity of alginate/chitosan based osteoplastic nanocomposites loaded with inorganic nanoparticles.

The influence of two nanostructured osteoplastic materials with different compositions: i) alginate (Alg) matrix, loaded with Zn ions and nanostructured hydroxyapatite (HA) - S1/HA-Zn, and ii) chitosan (CS) matrix loaded with brushite nanoparticles (NPs, dicalcium phosphate dihydrate, DCPD) - S2/DCPD on the healing of an experimental femoral diaphysis defect was investigated. The structure of cellular elements and the lacunar tubular system of the regenerated bone tissue were studied by electron microscopy. Osteogenic cells on the surface and inside S1/HA-Zn formed bone tissue.

In Vivo feature of the regenerative potential of chitosan and alginate based osteoplastic composites doped with calcium phosphates, zinc ions, and vitamin D2.

Purpose: In vivo comparison of the regenerative potential of two calcium phosphate-biopolymer osteoplastic composites: а) based on alginate (Alg) and hydroxyapatite (HA) - Alg/HA/CS/Zn/D2, b) based on chitosan (CS) and brushite (DCPD) - CS/DCPD/D2.

Materials And Methods: 36 white male laboratory rats aged six months were used. A defect to the bone marrow canal in the middle of the femur diaphysis was made with a dental bur of 2 mm.

Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.

The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Me) Ca, Zn, and Cu was created as a wound dressing. The effect of Me and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown. Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.

Hydroxyapatite-biopolymers-ZnO composite with sustained Ceftriaxone release as a drainage system for treatment of purulent cavities.

Composite based on nano-sized hydroxyapatite (HA), zinc oxide (ZnO), chitosan (CS), alginate (Alg) with the function of sustained Ceftriaxone (CF) release was created as molecular sorption-aspiration drainage system (SADS), designed for the treatment of purulent cavities of various genesis, including peritonitis. ZnO stabilizes the composite structurally, reducing the swelling by 1.5 and porosity by 1.