Publications by authors named "L Suchomelova"
Article Synopsis
- The study investigates the link between chronic epilepsy and aggressive behaviors observed in juvenile rats that experienced limbic status epilepticus (SE), challenging the skepticism in the field regarding this association.
- After inducing SE with lithium and pilocarpine, behavioral tests revealed that the experimental rats displayed significantly higher aggression levels compared to control rats, exhibiting dominance and increased fighting behaviors.
- The findings suggest that this experimental model could help clarify the intricate connections between seizures, epilepsy, and aggression, highlighting factors like age and type of seizures in understanding their long-term impacts.
The transition from single seizures to status epilepticus (SE) is associated with malaptive trafficking of synaptic gamma-aminobutyric acid (GABA) and glutamate receptors. The receptor trafficking hypothesis proposes that these changes are key events in the development of pharmacoresistance to antiepileptic drugs (AEDs) during SE, and that blocking their expression will help control drug-refractory SE (RSE). We tested this hypothesis in a model of SE induced by very high-dose lithium and pilocarpine (RSE), and in a model of SE induced by sc soman.
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- Cholinergic status epilepticus (SE) disrupts the balance between inhibitory GABA receptors and excitatory NMDA/AMPA receptors, leading to treatment resistance and increased seizures.* -
- Research using benzodiazepine-refractory SE models found that combining GABA agonists (like midazolam or diazepam) with NMDA antagonists (like ketamine) effectively terminates seizures that do not respond to standard treatments.* -
- The combination treatment also minimizes neuronal damage and cognitive deficits, with three-drug regimens showing enhanced effectiveness without increased toxicity, suggesting a promising approach for improving SE therapy.*
Article Synopsis
- Treatment of status epilepticus in infants and children is complex and requires understanding developmental processes to grasp the physiological effects of severe seizures.
- * Research using basic experimental models is essential to identify mechanisms for improving seizure treatment and outcomes.
- * It's crucial to terminate seizures quickly, but understanding their impact on the developing brain and the potential negative effects of common seizure medications is necessary to prevent long-term deficits.
Objective: To evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE).
Methods: Rats were treated with BRV (10 mg/kg) 10 min after initiation of perforant path stimulation (PPS) as early treatment; or BRV (10-300 mg/kg), DZP (1 mg/kg), or BRV (0.3-10 mg/kg) + DZP (1 mg/kg) 10 min after the end of PPS (established SSSE).