Publications by authors named "L Stempora"
Article Synopsis
- Natural killer (NK) cells play a crucial role in managing both viral infections and immune responses during kidney transplants in children, as shown in a study using data from the CTOTC project.
- The study analyzed NK cell phenotypes in 98 pediatric kidney transplant patients and found specific NK cell traits linked to either viral infections or alloimmune events, such as acute rejection.
- These findings suggest that understanding NK cell profiles could help distinguish between risk factors for infections versus those for immune responses after transplantation.
Objectives: To characterize and quantify accumulating immunologic alterations, pre and postoperatively in patients undergoing elective surgical procedures.
Background: Elective surgery is an anticipatable, controlled human injury. Although the human response to injury is generally stereotyped, individual variability exists.
Background: Thoracic injury can cause impairment of lung function leading to respiratory complications such as pneumonia (PNA). There is increasing evidence that central memory T cells of the adaptive immune system play a key role in pulmonary immunity. We sought to explore whether assessment of cell phenotypes using flow cytometry (FCM) could be used to identify pulmonary infection after thoracic trauma.
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- The study focused on creating personalized prognostic models to improve the management of trauma patients post-injury, using a range of clinical, immunological, and administrative data.
- Data was collected from 179 trauma patients at Level 1 centers over four years, with models predicting outcomes such as ventilator-associated pneumonia and acute kidney injury.
- Machine learning techniques yielded good predictive accuracy (areas under the curve between 0.70 to 0.91), suggesting that integrating diverse data types can effectively identify patients with complicated clinical paths.
Background: Malnutrition, including obesity and undernutrition, among children is increasing in prevalence and is common among children on renal replacement therapy. The effect of malnutrition on the pre-transplant immune system and how the pediatric immune system responds to the insult of both immunosuppression and allotransplantation is unknown. We examined the relationship of nutritional status with post-transplant outcomes and characterized the peripheral immune cell phenotypes of children from the Immune Development of Pediatric Transplant (IMPACT) study.
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