Temperature Excursion of Intravitreal Anti-VEGF Agents During Home Storage.

Importance: Some patients worldwide are asked to acquire an anti-vascular endothelial growth factor (anti-VEGF) agent from a pharmacy, store it, and then bring it to a physician for intravitreal injection (IVT). Anti-VEGF agents must be stored in the refrigerator to avoid bacterial contamination or denaturation. Some cases of severe intraocular inflammation have been reported following IVT of more recently approved anti-VEGF agents, which might be explained by thermal instability.

Development of Primal World Beliefs.

Primal world beliefs ("primals") capture individuals' basic understanding of what sort of world this is. How do children develop beliefs about the nature of the world? Is the world a good place? Safe or dangerous? Enticing or dull? Primals were initially introduced in social and personality psychology to understand beliefs about the world as a whole that may influence well-being and personality. This article introduces the concept of primals to developmental scientists and reviews preliminary research examining how primals relate to sociodemographic and well-being indicators.

International Comparison of Quality Indicators for Adults Hospitalized for Heart Failure: A Systematic Review.

Background: There is limited international agreement on defining care quality for the millions of people hospitalized with heart failure worldwide. Our objective was to compare and measure agreement across existing internationally published quality indicators (QIs) for the care of adults hospitalized for heart failure.

Methods: Systematic review and evidence gap map of internationally published articles reporting on QIs for adults hospitalized for heart failure, using PubMed, MEDLINE, EMBASE, and TRIP from inception to July 18, 2022.

Artificial intelligence-based prediction of neurocardiovascular risk score from retinal swept-source optical coherence tomography-angiography.

The recent rise of artificial intelligence represents a revolutionary way of improving current medical practices, including cardiovascular (CV) assessment scores. Retinal vascular alterations may reflect systemic processes such as the presence of CV risk factors. The value of swept-source retinal optical coherence tomography-angiography (SS OCT-A) imaging is significantly enhanced by image analysis tools that provide rapid and accurate quantification of vascular features.

Parenting Risk and Protective Factors in the Development of Conduct Problems in Seven Countries.

This study advances the understanding of risk and protective factors in trajectories of conduct problems in adolescence in seven countries that differ widely on a number of sociodemographic factors as well as norms related to adolescent behavior. Youth- and parent-report data from 988 adolescents in seven countries (Colombia, Italy, Kenya, Philippines, Sweden, Thailand, and the USA) who were followed longitudinally from ages 10 to 18 (yielding 6872 total data points) were subject to latent class growth analysis. A 4-class model provided the best fit to the data: Late Starters, Alcohol Experimenters, Mid-Adolescent Starters, and Pervasive Risk Takers.