Publications by authors named "L Steelman"
Article Synopsis
- Isocitrate dehydrogenase (IDH)-mutant grade 2 gliomas are aggressive brain tumors, and vorasidenib is a promising oral treatment that targets these mutations and showed preliminary effectiveness.
- A randomized phase 3 trial involved 331 patients with untreated residual or recurrent gliomas, comparing vorasidenib to a placebo over 28-day cycles, focusing on progression-free survival as the main outcome.
- Results indicated that patients taking vorasidenib had significantly longer progression-free survival (27.7 months) compared to those on placebo (11.1 months) and experienced better outcomes before needing further treatment, although adverse effects were more common in the vorasidenib group.
Article Synopsis
- Vorasidenib and ivosidenib are drugs that target mutant forms of isocitrate dehydrogenase (mIDH) and have shown promise in treating recurrent low-grade gliomas (IGG).
- A Phase 1 trial with 49 patients assessed the effectiveness of these drugs by measuring the reduction of D-2-hydroxyglutarate (2-HG), a byproduct of mIDH enzymes, which dropped significantly following treatment.
- Vorasidenib demonstrated better brain penetrance and more consistent 2-HG suppression than ivosidenib, leading to its selection for further Phase 3 testing.
Background: Inhibition of the isocitrate dehydrogenase (IDH)-mutant enzyme is a novel therapeutic target in IDH-mutant gliomas. Imaging biomarkers of IDH inhibitor treatment efficacy in human IDH-mutant gliomas are largely unknown. This study investigated early volumetric, perfusion, and diffusion MRI changes in IDH1-mutant gliomas during IDH inhibitor treatment.
View Article and Find Full Text PDFApproximately 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is the fourth leading cause of cancer death world-wide. Therapies for PDAC are largely ineffective due to the dense desmoplastic tumor microenvironment which prevents chemotherapeutic drugs and small molecule inhibitors from exerting effective anti-cancer effects.
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