Effects of vimentin on the migration, search efficiency, and mechanical resilience of dendritic cells.

Dendritic cells use amoeboid migration to pass through narrow passages in the extracellular matrix and confined tissue in search for pathogens and to reach the lymph nodes and alert the immune system. Amoeboid migration is a migration mode that, instead of relying on cell adhesion, is based on mechanical resilience and friction. To better understand the role of intermediate filaments in ameboid migration, we studied the effects of vimentin on the migration of dendritic cells.

Persistence-Speed Coupling Enhances the Search Efficiency of Migrating Immune Cells.

Migration of immune cells within the human body allows them to fulfill their main function of detecting pathogens. We present experimental evidence showing the optimality of the search strategy of these cells, which is of crucial importance to achieve an efficient immune response. We find that the speed and directional persistence of migrating dendritic cells in our in vitro experiments are highly correlated, which enables them to reduce their search time.

Deterministic actin waves as generators of cell polarization cues.

Dendritic cells "patrol" the human body to detect pathogens. In their search, dendritic cells perform a random walk by amoeboid migration. The efficiency of pathogen detection depends on the properties of the random walk.

The microRNA-205-5p is correlated to metastatic potential of 21T series: A breast cancer progression model.

MicroRNA is a class of noncoding RNAs able to base pair with complementary messenger RNA sequences, inhibiting their expression. These regulatory molecules play important roles in key cellular processes including cell proliferation, differentiation and response to DNA damage; changes in miRNA expression are a common feature of human cancers. To gain insights into the mechanisms involved in breast cancer progression we conducted a microRNA global expression analysis on a 21T series of cell lines obtained from the same patient during different stages of breast cancer progression.