Publications by authors named "L Spatola"

Cardiac surgery patients are potentially exposed to an acute inflammatory host response with a huge release of both pro- and anti-inflammatory cytokines both through intrinsic (e.g., tissue damage, endothelial injury) and extrinsic (e.

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Sacubitril/Valsartan is a combination of neprilysin inhibitor and angiotensin II receptor blocker that proved its own efficacy and safety in heart failure patients to ameliorate cardiovascular morbidity and mortality compared to angiotensin II-converting enzyme inhibitors alone. However, end-stage renal disease patients have not been included in the randomized controlled trials, so the beneficial effects as well as the risk profile of this association remain still undefined in these patients. Only observational studies on this drug association have been carried out in end-stage renal disease patients investigating mostly biohumoral or echocardiographic markers.

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Article Synopsis
  • - Lithium is a widely used treatment for mania and bipolar disorders since 1950, but its potential for causing serious health issues is often overlooked, especially in cases requiring advanced treatments like extracorporeal therapy.
  • - The acceptable lithium serum range is between 0.6 and 1.3 mmol/L, with varying levels of toxicity observed at higher concentrations, leading to complications in cardiovascular, central nervous system, and kidney functions.
  • - The review covers a clinical case of lithium intoxication, outlines the types of health problems linked to excessive lithium levels, and discusses when extracorporeal treatment is necessary.
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Background: The known risks and benefits of native kidney biopsies are mainly based on the findings of retrospective studies. The aim of this multicentre prospective study was to evaluate the safety of percutaneous renal biopsies and quantify biopsy-related complication rates in Italy.

Methods: The study examined the results of native kidney biopsies performed in 54 Italian nephrology centres between 2012 and 2020.

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The etiopathogenesis of obesity-related chronic kidney disease (CKD) is still scarcely understood. To this aim, we assessed the effect of high-fat diet (HF) on molecular pathways leading to organ damage, steatosis, and fibrosis. Six-week-old male C57BL/6N mice were fed HF diet or normal chow for 20 weeks.

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