Publications by authors named "L Sorodoc"
Article Synopsis
- Obesity is a significant risk factor for venous thromboembolism (VTE) and poses unique challenges in anticoagulation management due to limited research on how extreme body weight affects medication outcomes.
- This review focuses on patients with a body mass index (BMI) of 40 kg/m² or higher, analyzing various anticoagulants' dosages, efficacy, and safety for both prevention and treatment of VTE.
- The study emphasizes the need for personalized treatment strategies and careful monitoring, especially for specific groups like cancer patients or those with kidney issues, given the insufficient evidence available for effective anticoagulant therapy in morbidly obese individuals.
Predictors of Myocardial Fibrosis Detected by CMR in Patients With Idiopathic PVCs.
Ann Noninvasive Electrocardiol
November 2024
Article Synopsis
- Premature ventricular contractions (PVCs) are common in patients but can indicate underlying heart disease in some cases, particularly in 16% of idiopathic PVC patients.
- This study focused on 94 patients with frequent PVCs, analyzing how the morphology of these contractions relates to myocardial scarring found through cardiac magnetic resonance (CMR) imaging, especially looking at late gadolinium enhancement (LGE) and its implications for treatment.
- Results showed significant associations between LGE prevalence and factors like age, sex, and PVC characteristics, revealing that a high percentage of patients with PVCs had underlying myocardial scarring, with specific patterns in PVC morphology linked to LGE presence.
Article Synopsis
- Amiodarone is a highly effective antiarrhythmic drug used to treat conditions like atrial fibrillation and ventricular arrhythmias, functioning across all four classes of antiarrhythmics.
- It has a long half-life and complex pharmacokinetics, which can lead to prolonged effects even after stopping the medication, making regular monitoring for side effects like thyroid issues and lung damage essential.
- This paper aims to offer a detailed review of amiodarone's uses, dosing guidelines, interactions with other medications, and necessary monitoring practices.
Heyde's syndrome (HS) represents an association between aortic stenosis and intestinal angiodysplasias, and it has been demonstrated that acquired von Willebrand disease plays a pivotal role in the pathophysiology of this syndrome. In patients with HS, von Willebrand factor deficiency represents an additional risk factor, further contributing to the risk of bleeding and anemia. We present the case of an 86-year-old patient diagnosed with HS and von Willebrand deficiency in 2018.
View Article and Find Full Text PDFThis study investigates the combined treatment of secukinumab (SECU) and magnolol (MAGN) in a mouse model of LPS-induced ALI overlapped with allergic pulmonary inflammation, aiming to better understand the mechanism behind this pathology and to assess the therapeutic potential of this novel approach in addressing the severity of ALI. The combined treatment reveals intricate immunomodulatory effects. Both treatments inhibit IL-17 and promote M2 macrophage polarization, which enhances anti-inflammatory cytokine production such as IL-4, IL-5, IL-10, and IL-13, crucial for lung repair and inflammation resolution.
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