Publications by authors named "L Soret"

COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). The SARS-CoV-2 pandemic has unveiled complex pathophysiological mechanisms underpinning COVID-19, notably inducing a systemic acquired vascular hemopathy characterized by endothelial dysfunction and intussusceptive angiogenesis, a rapid vascular remodeling process identified as a hallmark in severe COVID-19 cases affecting pulmonary and cardiac tissues. Stem cell migration have been proposed as significant regulators of this neoangiogenic process.

View Article and Find Full Text PDF

We present a case of a 48-year-old woman with a fortuitous discovery of macrocytic anemia and thrombocytopenia. Serum folate and vitamin B12 levels were normal. However, due to the presence of indirect signs of cobalamin deficiency, such as elevated homocysteine and methylmalonic acid, and signs of dyserythropoiesis on the bone marrow aspirate, pernicious anemia was suspected.

View Article and Find Full Text PDF

Background: Bone marrow aspiration (BMA) is a medical procedure necessary to the diagnosis and monitoring of patients with hematological or nonhematological disorders. This procedure is considered painful, and patients are generally anxious before and during BMA.

Objective: This study assesses the effect of immersive virtual reality on pain during BMA.

View Article and Find Full Text PDF
Article Synopsis
  • COVID-19 is recognized in the United Nations' strategic development goals as an endothelial disease, prompting research into the role of circulating endothelial extracellular vesicles (EVs) in patient outcomes upon hospital admission.* -
  • A study of 60 COVID-19 patients found that higher levels of endothelial EVs expressing E-selectin (CD62E+) were significantly linked to critical disease status and increased in-hospital mortality.* -
  • Specifically, patients with CD62E+ EV levels ≥ 88,053 EVs/μL at admission had a notably higher risk of death, suggesting that measuring these EVs could help identify high-risk patients early on.*
View Article and Find Full Text PDF

Chemotherapy resistance is the main cause of treatment failure in acute myeloid leukemia (AML) and has been related to ATP-binding cassette (ABC) transporter activity. However, the links between ABC activity, immunophenotype, and molecular AML parameters have been poorly evaluated. Moreover, the prognostic value of ABC activity, when compared to new molecular markers, is unknown.

View Article and Find Full Text PDF