Publications by authors named "L Smeeth"
Background: Although drug interactions between clarithromycin/erythromycin/fluconazole and direct oral anticoagulants (DOACs) are mechanistically plausible, it is uncertain whether they are clinically relevant.
Objective: To investigate the association between co-prescribed DOACs and antimicrobials and bleeding, cardiovascular disease and mortality.
Methods: We identified DOAC users in the Clinical Practice Research Datalink Aurum from 1/1/2011-29/3/2021.
Background: Direct oral anticoagulants (DOACs) have been reported to be associated with a higher risk of mortality compared with an older alternative, warfarin using primary care data in the United Kingdom (UK). However, other studies observed contradictory findings. We therefore aimed to investigate the association between mortality and warfarin, compared with DOACs.
View Article and Find Full Text PDFMultimorbidity data is typically analysed by tallying disease counts, which overlooks nuanced relationships among conditions. We identified clusters of multimorbidity and subpopulations with varying risks and examined their association with all-cause mortality using a data-driven approach. We analysed 8-year follow-up data of people ≥35 years who were part of the CRONICAS Cohort Study, a multisite cohort from Peru.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the potential drug interaction between direct oral anticoagulants (DOACs) and statins (specifically atorvastatin and simvastatin) regarding bleeding risks and cardiovascular outcomes.
- Analyzing data from a large cohort, the results indicate that there is no significant difference in risk for major outcomes when DOACs are co-prescribed with atorvastatin/simvastatin compared to other statins.
- However, in certain cases, users of atorvastatin and simvastatin showed increased odds of specific bleeding events and higher mortality rates when initiating DOAC therapy, suggesting the need for careful monitoring.