Publications by authors named "L Skelley"
Article Synopsis
- A systematic review was conducted to identify risk factors for recurrence of squamous cell carcinoma in situ (SCCIS), focusing on various treatment approaches and factors linked to tumor recurrence.
- The analysis showed that immunosuppression was the only factor significantly associated with an increased risk of recurrence, while other possible contributors like tumor size and depth lacked strong supportive data.
- The authors concluded that recognizing factors such as subclinical tumor extension might be important in treatment decisions for SCCIS and emphasized the need for further research to better understand recurrence risks and treatment efficacy.
Medical student musculoskeletal education: an institutional survey.
J Bone Joint Surg Am
October 2012
Background: Since the 1910 Flexner Report, medical education continues to undergo curriculum and graduation guideline reform to meet the needs of physicians and patients. Our aims were to (1) assess the quality of musculoskeletal education at our institution's School of Medicine by reporting the results of the Freedman and Bernstein examination among our medical students across all four years of training, and (2) stratify results according to medical school year, educational module, and intended career.
Methods: We surveyed the 460 2009-2010 School of Medicine students via e-mail.
Clinical observations and epidemiological surveys indicated that the prevalence of hypertension and heart diseases is increased in cold regions or during winter. Cold exposure increased NADPH oxidase gp91(phox) protein expression in heart, kidneys, and aorta in rats. The aim of this study was to investigate if RNA interference (RNAi) silencing of gp91(phox) would attenuate cold-induced hypertension and cardiovascular and renal damage.
View Article and Find Full Text PDFThe sarco/endoplasmic reticulum (SER) Ca(2+) pool is refilled by the SER Ca(2+) pump (SERCA) using cytosolic Ca(2+) and/or extracellular Ca(2+) entering the cell. The effects of the SERCA pump inhibitor cyclopiazonic acid (CPA) were studied in pig coronary artery smooth muscle using two protocols. In protocol A, the SERCA pump was inhibited by adding CPA to cells/tissues in Ca(2+)-containing solution, whereas in protocol B, CPA was added to cells/tissues in Ca(2+)-free solution, followed by reintroduction of extracellular Ca(2+).
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