Publications by authors named "L Siyi"
Evaluating the Relationship between Cathepsins and Papillary Thyroid Carcinoma: A Mendelian Randomization Study.
Endocr Metab Immune Disord Drug Targets
January 2025
Background: Papillary Thyroid Carcinoma (PTC) is the most common thyroid cancer, with an etiology and progression that are not fully understood. Research suggests a link between cathepsins and PTC, but the causal nature of this link is unclear. This study uses Mendelian Randomization (MR) to investigate if cathepsins causally influence PTC risk.
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- The study aimed to assess emodin's impact on corneal inflammation and new blood vessel growth following an alkali burn injury.
- Emodin was found to effectively target VEGFR2, leading to reduced cell migration, invasion, and angiogenesis in laboratory tests with human endothelial cells.
- In a mouse model, emodin treatment decreased inflammation and neovascularization, correlating with lower levels of VEGFR2 and related signaling proteins compared to controls.
Objective: To investigate the safety and efficacy of abdominal radical hysterectomy (ARH) and laparoscopic radical hysterectomy (LRH) in managing early-stage cervical cancer.
Methods: This retrospective study comprised patients with FIGO stage IA1 with lymphovascular space invasion (LVSI), IA2, and IB1 cervical cancer who underwent radical hysterectomy performed by a single gynecologic oncology team at Peking Union Medical College Hospital from 2000-2018. The clinicopathological characteristics, surgical outcomes, and survival outcomes were compared between the two groups.