[ANTI-Hsp60 ANTIBODIES IN ARTERIAL HYPERTENTION DIFERENT DEGREE OF SEVERITY].

More than 12.1 million people with hypertension (32.2% of the adult population) were registered in Ukraine according to the official statistics on 1 January 2011.

Akt1 expression and activity at different stages in experimental heart failure.

Loss of function or/and death of cardiomyocytes is one of the major contributing factors in the development of heart failure. Cytosolic Hsp60 can directly interact and regulate activation of some kinases and sequestrate certain proapoptotic molecules to avoid the cardiomyocyte apoptosis. We assumed that Akt1 kinase, a downstream effector of PI3 kinase, can interact with Hsp60.

Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy.

Recently, it has been suggested that some heat shock proteins such as Hsp70 and Hsp60 are involved in autoimmune diseases including cardiospecific ones. In this work we focused on the involvement of another wellknown heat shock protein, Hsp90, and its novel co-chaperone,Sgt1, in dilated cardiomyopathy (DCM). We found that the level of autoantibodies against these two proteins was significantly higher in patients with DCM and ischemic heart disease than in sera of healthy donors.

[Application of modified frey operation for reduction of the autoimmune aggression severity to pancreatic tissues in patients with fibrous-degenerative pancreatitis].

Investigation of antibodies to the DNA-topoisomerase-1, the marker for autoimmune process in the blood serum, was conducted in 22 patients with chronic fibrous-degenerative pancreatitis, operated on in the clinic. The trustworthy raising of the antibodies titer in comparison with such in healthy donors was noted. In comparative analysis of the index in patients before and after the operation it was established, that in 12 of them after the standard draining operation it did not change within up to 12 months, in 10 patients, after Frey operation, performed in our modification, it had lowered almost twice.

Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.

Physiological stresses (heat, hemodynamics, genetic mutations, oxidative injury and myocardial ischemia) produce pathological states in which protein damage and misfolded protein structures are a common denominator. The specialized proteins family of antistress proteins - molecular chaperons (HSPs) - are responsible for correct protein folding, dissociating protein aggregates and transport of newly synthesized polypeptides to the target organelles for final packaging, degradation or repair. They are inducible at different cell processes such as cell division, apoptosis, signal transduction, cell differentiation and hormonal stimulation.