Publications by authors named "L Shrestha"
Background: Nepal, like other low- and middle-income countries, is experiencing a rapid increase in the number of older adults and the rate of aging in the population. This has increased the number of older adults with age-associated chronic illnesses, which in turn will escalate the demand for specialized healthcare and long-term care in Nepal. However, very little is known regarding the current healthcare system and health policies for older adults in Nepal.
View Article and Find Full Text PDFObjective: Different definitions of thyroid dysfunction during pregnancy may lead to under or overtreatment. The aims of this study were to (1) define population-based pregnancy-specific reference ranges for thyroid dysfunction during early pregnancy in Nepal and assess the impact of antibody positivity, (2) quantify the diagnostic impact of population-based reference ranges compared with current practice and (3) assess the determinants of thyroid function and antibody positivity.
Methods: A total of 800 healthy pregnant women aged 20-40 years in the Bhaktapur municipality were included.
Article Synopsis
- * This study analyzes the impact of coordinated sample transfers on laboratory efficiency and wait times during high demand in 2021.
- * Findings suggest that centralized coordination and strategic partnerships can significantly improve diagnostic network performance, providing important recommendations for future pandemic preparedness.
Background: Current literature informs us that bivalent vaccines will generate a broader serum neutralizing antibody response to multiple SARS-CoV-2 variants, but studies on how this breadth relates to the memory B cell (MBC) and T cell responses are sparse. This study compared breadth of neutralising antibody, and memory B and T cell responses to monovalent or a bivalent ancestral/Omicron BA.1 COVID-19 booster vaccine.
View Article and Find Full Text PDFArticle Synopsis
- Nepal is a popular tourist destination known for activities like mountaineering and trekking, with Gosaikunda being a major pilgrimage site at an elevation of 4380 meters.
- The study aimed to assess the sleep quality of pilgrims at high altitudes, where hypobaric hypoxia leads to sleep disturbances like difficulty falling asleep and waking up early.
- Among 229 participants, 30% showed signs of insomnia based on the Athens Insomnia Scale, with daytime sleepiness being a common issue, although 70% reported no sleep disturbances.