Publications by authors named "L Shemesh-Bar"
Background: The incidence of colorectal cancer in young patients is increasing. It remains unclear if the disease has unique features in this age group.
Methods: This was a single-center, retrospective cohort study which included patients diagnosed with colorectal cancer at age ≤40 years in 1997-2013 matched 1:2 by year of diagnosis with consecutive colorectal cancer patients diagnosed at age >50 years during the same period.
Aim: This study evaluated the effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipid profile, oxidative stress, and high-sensitivity C-reactive protein (hsCRP) in type 2 diabetes mellitus patients.
Subjects And Methods: Forty diabetes patients, inadequately controlled on metformin, were randomly assigned to either sitagliptin (100 mg/day) or glibenclamide (5 mg/day) for 3 months. Following a 1-month washout period, a crossover switch from glibenclamide to sitagliptin and vice versa was performed for an additional 3 months.
Article Synopsis
- The study aimed to explore characteristics of colorectal cancer (CRC) in young patients (≤50 years) and identify any unique features compared to older patients (>50 years).
- Researchers analyzed the medical files of 406 patients (203 young, 203 older) diagnosed with CRC between 1997-2007, observing differences in demographics, tumor characteristics, and family history.
- Young patients demonstrated distinct traits, such as a higher prevalence of female cases, family cancer histories, and advanced-stage tumors at diagnosis, but age alone did not significantly predict patient outcomes.