Publications by authors named "L Sheldon"
Article Synopsis
- Traumatic brain injury (TBI) is a major cause of injury-related death and disability in the U.S., and managing neuroinflammation early is crucial for treatment.
- Pioglitazone, a drug that may reduce inflammation after TBI, shows potential but also has unknown long-term effects that can worsen brain conditions.
- Research in mice indicates that acute/subacute treatment with pioglitazone leads to negative outcomes, including brain damage and behavior changes, highlighting the need for sex-based considerations and further investigation before clinical use for TBI.
Background: Despite successful treatment regimens and remission rates of greater than 90%, early death is a concern for patients with acute promyelocytic leukemia (APL). The challenges surrounding proper care for APL are centered on the low volume of patients, which limits healthcare professionals' knowledge of disease management.
Objectives: The purpose of this project was to develop resources and present an educational module specific to managing patients newly diagnosed with APL.
Background: Despite the role of health information technology (HIT) in patient engagement processes and government incentives for HIT development, research regarding HIT is lacking among older adults with a high burden of chronic diseases such as cancer. This study examines the role of selected sociodemographic factors and cancer-related fatalistic beliefs on patient engagement expressed through HIT use for patient engagement in adults aged ≥65 years. We controlled for cancer diagnosis to account for its potential influence on patient engagement.
View Article and Find Full Text PDFAnimal disease models are important for neuroscience experimentation and in the study of neurodegenerative disorders. The major neurodegenerative disorder leading to motor impairments is Parkinson's disease (PD). The identification of hereditary forms of PD uncovered gene mutations and variants, such as loss-of-function mutations in PTEN-induced putative kinase 1 (Pink1) and the E3 ubiquitin ligase Parkin, two proteins involved in mitochondrial quality control, that could be harnessed to create animal models.
View Article and Find Full Text PDFPeriodontal Therapy: Patient Outcomes-Based or Profit Center-Based?
Compend Contin Educ Dent
July 2023
Article Synopsis
- - Multiple recent articles emphasize the need for outcomes-based and patient-centered guidelines in periodontal therapy.
- - The authors argue that periodontal treatment should be grounded in evidence-based practices that prioritize the patient's best interests.
- - They suggest that many patients with periodontal disease are not receiving adequate and timely care for their condition.