Repurposing Licensed Drugs with Activity Against Epstein-Barr Virus for Treatment of Multiple Sclerosis: A Systematic Approach.

Background: Epstein-Barr virus (EBV) is implicated as a necessary factor in the development of multiple sclerosis (MS) and may also be a driver of disease activity. Although it is not clear whether ongoing viral replication is the driver for MS pathology, MS researchers have considered the prospect of using drugs with potential efficacy against EBV in the treatment of MS. We have undertaken scientific and lived experience expert panel reviews to shortlist existing licensed therapies that could be used in later-stage clinical trials in MS.

Mental Health Care Utilization and Prescription Rates Among Children, Adolescents, and Young Adults in France.

Importance: Amid escalating mental health challenges among young individuals, intensified by the COVID-19 pandemic, analyzing postpandemic trends is critical.

Objective: To examine mental health care utilization and prescription rates for children, adolescents, and young adults before and after the COVID-19 pandemic.

Design, Setting, And Participants: This population-based time trend study used an interrupted time series analysis to examine mental health care and prescription patterns among the French population 25 years and younger.

Association between behavioral and sociodemographic factors and high subjective health among adolescents: a nationwide representative study in South Korea.

The need to understand subjective health has increased during the COVID-19 pandemic, given its substantial impact on lifestyle habits and perceptions. Thus, this study aimed to investigate the trends and association of subjective health with demographic and behavioral factors, primarily focusing on the change when the COVID-19 pandemic emerged. This study used data from the Korea Youth Risk Behavior Web-based Survey, comprising 1,190,468 adolescents aged 12-18 years (female, 48.

Agency Nurse Usage of Infusion Interoperability: Identifying Barriers and Improving Workflows.

Over the past several years, hospitals have utilized agency staffing to combat staffing shortages. Increased use of agency staffing presented an opportunity for implementation of an education project related to the potential variance in practice of permanent staffing, specifically with the use of infusion interoperability in the inpatient setting at the University of Pittsburgh Medical Center St Margaret hospital. Discussion around variables causing agency nurse setbacks with utilizing infusion interoperability while trying to meet the required standard laid the groundwork for this project.

Perspectives of Yukon's frontline health care workers during the COVID-19 pandemic.

The perspectives of Yukon's nurses and physicians can determine what might mitigate burnout and strengthen the response to the COVID-19 pandemic and/or future health emergencies. The study was conducted in the Yukon Territory, Canada in two phases: completion of the Copenhagen Burnout Inventory (CBI), and in-depth oral interviews. This paper will discuss the results of the interviews.