[Antigens of the HLA system in different types of diabetes mellitus].

HLA antigens (A, B, DR) of the tissues of 171 patients with different types of diabetes mellitus were investigated. Controls were 1867 healthy Leningrad residents (control I), not investigated with the GTT, and 38 pregnant women with the unchanged GTT during pregnancy (control II). Some features of the frequency of occurrence of individual antigens and their interlocular (HLA A, B) combinations in type I and type II diabetes mellitus and diabetes of pregnant women were established.

[Change in the incidence of HL-A antigens in diabetes mellitus].

Changes in the incidence of the HLA system antigens (A1, A2, A3, A9, A10, A11, A19, A28, A29, B5, B7, B8, B13, B14, B15, B16, B17, B18, B21, B22, B27, B35, B37, B40, B41) was studied in 1134 healthy persons and in 147 patients with diabetes mellitus. In comparison with healthy persons, patients with juvenile diabetes mellitus (62) displayed a significant increase in the incidence of antigens B8, B15, B35, and A10, and patients with adult diabetes mellitus with normal weight (35)--of antigen B8. When adult diabetes mellitus was accompanied by obesity (50) a significant rise in the occurrence of antigen A10 was revealed.

[Insulin and proinsulin content in the blood plasma in diabetes mellitus, determined by means of the gel filtration method].

With the aid of a simplified method of gel filtration the authors carried out separate determination of the immunoreactive insulin (IRI) and immunoreactive proinsulin (IRP) in 11 obese patients with diabetes mellitus and in 7 healthy persons during oral glucose tolerance test (GTT). In the presence of higher IRI, IRP, and general immunoreactivity (GIR) levels in patients in comparison with healthy persons the changes in IRI were similar to those of GIR in both groups: in healthy individuals the peak was observed 60, and in patients--120 minutes after glucose administration. A rise of IRP content occurred in both groups in 90 minutes, but in sick persons it was preceded by reduction of its level.