Publications by authors named "L Seguin"
Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated ganglioside GD3 at their surface. The increased level of GD3 expression on senescent cells that naturally occurs upon aging in liver, lung, kidney or bones leads to a strong suppression of NK-cell-mediated immunosurveillance.
View Article and Find Full Text PDFExtracellular vesicles (EVs) mediate intercellular communication. EVs are composed of a lipid bilayer and contain cytosolic proteins and RNAs. Studies highlight EVs striking functions in cell-cell crosstalk.
View Article and Find Full Text PDFObjective: A major concern for cancer survivors after treatment is the Fear of Cancer Recurrence (FCR), which is the fear that cancer will reappear or progress. This fear can be exacerbated by medical uncertainty about the future, leading to harmful obsession and having a negative impact on quality of life. This study aims to develop a predictive Machine Learning (ML) model using healthcare reimbursement data to better predict FCR and understand the factors influencing FCR in women with breast cancer five years after their diagnosis.
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- The study investigates how Obstructive Sleep Apnea (OSA) contributes to respiratory issues and cardiac arrhythmias in patients after general anesthesia during the night following surgery.
- It involved analyzing patients with varying degrees of OSA and assessing the frequency of hypoxic episodes and cardiac irregularities during their first and third nights post-operation.
- Findings show that patients with moderate OSA experienced a higher incidence of cardiac arrhythmias linked to hypoxia on the third night after surgery, highlighting the need for better preoperative screening for OSA.
Research comparing monogamous and non-monogamous relationships on well-being indicators across diverse populations have yielded inconsistent findings. The present study investigates sociodemographic characteristics, as well as personal and relational outcomes, across different relationship configurations. Data were drawn from an online community-based sample of 1,528 LGBTQ+ persons aged 18 years and older in Quebec, Canada.
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