Publications by authors named "L Schwendimann"
Infants born very preterm (below 28 weeks of gestation) are at high risk of developing neurodevelopmental disorders, such as intellectual deficiency, autism spectrum disorders, and attention deficit. Preterm birth often occurs in the context of perinatal systemic inflammation due to chorioamnionitis and postnatal sepsis. In addition, C-section is often performed for very preterm neonates to avoid hypoxia during a vaginal delivery.
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- Inadequate collaboration in healthcare can result in medical errors, making interdisciplinary teamwork training crucial, and virtual reality (VR) simulations offer a cost-effective solution for such training.
- The study involved 42 medical and nursing students participating in a VR-based scenario, where their performance was evaluated using the Team Emergency Assessment Measure (TEAM), which showed high reliability and internal consistency.
- Results indicated that the TEAM tool is a reliable and valid way to assess team dynamics in VR training, emphasizing its potential to enhance medical education and improve interdisciplinary assessments in various learning contexts.
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- Pediatric traumatic brain injury (TBI) leads to long-term neuroinflammation and disabilities, especially in children, highlighting the need to study its lasting effects on brain development.
- In a mouse model, researchers induced TBI and then assessed neuroinflammation, myelination, and behavioral changes over time, finding robust inflammation and various neurodevelopmental issues.
- The findings revealed persistent behavioral deficits, such as anxiety and social interaction problems, linked to white matter damage, establishing the mouse model as a valuable tool for future research on TBI outcomes.
Introduction: Therapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflammation before a hypoxic-ischemic insult. We aimed to compare newborn piglets with lipopolysaccharide-sensitized hypoxia-ischemia treated with and without therapeutic hypothermia with regards to measures of neuroprotection.
View Article and Find Full Text PDFApproximately 15 million babies are born prematurely every year and many will face lifetime motor and/or cognitive deficits. Children born prematurely are at higher risk of developing perinatal brain lesions, especially white matter injuries (WMI). Evidence in humans and rodents demonstrates that systemic inflammation-induced neuroinflammation, including microglial and astrocyte reactivity, is the prominent processes of WMI associated with preterm birth.
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