Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn's disease. The ENIGMA study.

Food additives have been linked to the pro-inflammatory microbial dysbiosis associated with Crohn's disease (CD) but the underlying ecological dynamics are unknown. Here, we examine how selection of food additives affects the growth of multiple strains of a key beneficial bacterium (), axenic clinical isolates of proinflammatory bacteria from CD patients (, and spp.), and the consortia of mucosa-associated microbiota recovered from multiple Crohn's disease patients.