Publications by authors named "L Schoof"
Objective: The 2017 McDonald criteria continued the separation of diagnostic criteria for relapsing-remitting multiple sclerosis (RRMS) and primary progressive MS (PPMS) for historical, rather than biological, reasons. We aimed to explore the feasibility of a single, unified set of diagnostic criteria when applied to patients with suspected PPMS.
Methods: We retrospectively identified patients evaluated for suspected PPMS at 5 European centers.
The recurrence of disease activity after ocrelizumab discontinuation in multiple sclerosis.
Mult Scler Relat Disord
November 2024
Introduction: Ocrelizumab (OCR) is a highly effective treatment of multiple sclerosis (MS), and B cell repopulation profiles suggest that it might be used as an immune reconstitution therapy. However, data on disease recurrence after stopping treatment with OCR are scarce. Our objective was to evaluate the recurrence of disease activity after OCR discontinuation.
View Article and Find Full Text PDFLate diagnosis of Marfan syndrome is associated with unplanned aortic surgery and cardiovascular death.
J Thorac Cardiovasc Surg
September 2024
Background: Marfan syndrome (MFS) guidelines recommend optimal pharmacologic therapy (OPT) and replacement of the ascending aorta (RAA) at 5.0 cm in diameter to prevent acute type A aortic dissection (ATAAD) and death. The effect of early MFS diagnosis and initiation of therapy on outcomes is not known.
View Article and Find Full Text PDFA hypertrophic distal fascicle of the anterior tibiofibular ligament is associated with a high rate of osteochondral lesions of the talus.
Knee Surg Sports Traumatol Arthrosc
September 2024
Article Synopsis
- This study aimed to investigate how common osteochondral lesions (OCLs) are in the lateral talar dome among patients with anterior ankle impingement who also have a thickened segment of the anterior tibio-fibular ligament.
- Researchers reviewed the cases of 40 patients who underwent arthroscopy for ankle impingement, assessing various clinical outcomes before and after surgery.
- The results showed that 90.6% of patients had a hypertrophic ligament, and 75.9% had OCLs, with postoperative scores improving significantly, indicating a link between the ligament thickness and the presence of OCLs.
Purpose: To assess outcomes following Achilles in-office needle tendoscopy (IONT) for the treatment of chronic Achilles tendinopathy (cAT) at a minimum 12-month follow-up.
Methods: A retrospective case series was conducted to evaluate patients who underwent Achilles IONT for cAT between January 2019 and December 2022. Inclusion criteria were patients ≥18 years of age and clinical history, physical history, and magnetic resonance imaging findings consistent with cAT who did not respond to a minimum of 3 months of conservative management for which each patient underwent Achilles IONT and had a minimum 12-month follow-up.