Publications by authors named "L Schoderboeck"
Dopaminergic neurons are the predominant brain cells affected in Parkinson's disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson's disease, dopaminergic neurons have been generated from human-skin-cell-derived induced pluripotent stem cells. Originally, induced pluripotent stem-cell-derived dopaminergic neurons were generated using small molecules.
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- Soluble amyloid precursor protein-alpha (sAPPα) helps regulate neuron function and memory, and it has potential neuroprotective effects, especially in the context of Alzheimer's disease.
- In a study using APP/PS1 mouse models of Alzheimer's, sAPPα was delivered via an adeno-associated virus, leading to restored proliferation of new brain cells (neurogenesis) but not survival of those cells.
- The overexpression of sAPPα also reduced amyloid-beta plaque load, suggesting it may serve as a therapeutic approach to combat cognitive decline associated with Alzheimer’s by enhancing neurogenesis.
Neuronal Ceroid Lipofuscinosis (NCL), also known as Batten disease, is an incurable childhood brain disease. The thirteen forms of NCL are caused by mutations in thirteen CLN genes. Mutations in one CLN gene, CLN5, cause variant late-infantile NCL, with an age of onset between 4 and 7 years.
View Article and Find Full Text PDFAdeno-associated viral (AAV) vectors are attractive tools for central nervous system (CNS) gene therapy because some vectors can cross the blood-brain barrier (BBB), allowing them to be used as minimally invasive treatments. A novel AAV vector recently evolved , AAV-PHP.eB, has been reported to cross the BBB more effectively than the existing gold standard AAV9, but not under all conditions.
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