Associations between ADHD traits and self-reported strengths in the general population.

Background: ADHD research has had a clear focus on symptoms, their negative consequences and the treatment of ADHD. However, previous qualitative research found that people with a diagnosis of ADHD also self-report to experience strengths related to their ADHD. This is one of the first quantitative studies to investigate multiple self-reported strengths in relation to ADHD traits in a general population sample.

A qualitative and quantitative study of self-reported positive characteristics of individuals with ADHD.

Research in Attention-deficit/hyperactivity disorder (ADHD) has had a clear focus on treatment and the dysfunction in specific situation associated with the condition. However, self-report, observational and anecdotal evidence indicates that there are also positive aspects associated with ADHD. Research on the potential positive features in individuals with an ADHD diagnosis is still limited, especially studies with larger representative samples.

Repurposing CRISPR/Cas9 for in situ functional assays.

RNAi combined with next-generation sequencing has proven to be a powerful and cost-effective genetic screening platform in mammalian cells. Still, this technology has its limitations and is incompatible with in situ mutagenesis screens on a genome-wide scale. Using p53 as a proof-of-principle target, we readapted the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR associated 9) genome-editing system to demonstrate the feasibility of this methodology for targeted gene disruption positive selection assays.

The value of transoesophageal echocardiography for diagnosis of thoracic aorta pathology.

The potential of transoesophageal echocardiography for preoperative diagnosis of thoracic aorta pathology was evaluated in 15 patients with aortic dissection and 15 patients with aortic aneurysm. The transoesophageal echocardiographic findings were compared with 14 computed tomograms and 21 angiograms. Six patients underwent only transoesophageal echocardiography.