A New Mechanism for Formation of Glycine from Glyoxylic Acid: the Aza-Cannizzaro Reaction.

Glyoxylic acid and glycine are widely considered to have been important prebiotic building blocks. Several mechanistic routes have been previously examined for conversion of glyoxylic acid to glycine. Here we provide evidence for a new mechanistic path.

Generation of nanobodies from transgenic 'LamaMice' lacking an endogenous immunoglobulin repertoire.

Due to their exceptional solubility and stability, nanobodies have emerged as powerful building blocks for research tools and therapeutics. However, their generation in llamas is cumbersome and costly. Here, by inserting an engineered llama immunoglobulin heavy chain (IgH) locus into IgH-deficient mice, we generate a transgenic mouse line, which we refer to as 'LamaMouse'.

Improving the efficiency of urea-based fertilization leading to reduction in ammonia emission.

A problematic issue in agriculture is the high quantity of ammonia being released resulting in a partial loss of the nitrogen which is contained in urea fertilizers. Alignment with European Union legislation on the regulation of ammonia emission from mineral fertilizers after 2030, urea fertilizers with reduced ammonia emissions by at least 30% will be allowed to remain in use. Currently, laboratory and field tests are carried out to assess the effectiveness of inhibiting nitrogen losses from urea fertilizers.

Perdecanoic acid as a safe and stable medium-chain peracid for Baeyer-Villiger oxidation of cyclic ketones to lactones.

Stability studies dedicated to high-energy compounds for a series of linear peracids (C-C), including sensitivity to mechanical impulse (shock and friction), as well as electrical (spark) and thermal sensitivity (temperature and heat of decomposition), were presented in this work for the first time. Studies revealed that all peracids were insensitive to shock, while in the case of the other sensitivity tests sharp differences between results for C and C peracids were observed. Taking into account the relatively high initial temperature of decomposition (above 64 °C) perdecanoic acid was selected as a safe alternative to commonly used hazardous short-chain peracids.