Publications by authors named "L Savelyeva"
Background: Obesity is a potential risk factor for development of type 2 diabetes mellitus (T2DM). To achieve long-term weight reduction in patients with T2DM and obesity using comprehensive lifestyle management program (LMP).
Materials And Methods: This 48-week interventional, multicenter, parallel-group, open-label study included patients aged ≥18 years with T2DM and a body mass index (BMI) of 27-40 kg/m.
Article Synopsis
- - The study investigates telomere maintenance methods, specifically telomerase activation and alternative lengthening of telomeres (ALT), in primary and relapsed neuroblastomas, finding that ALT is linked to worse outcomes in patients.
- - Researchers analyzed 760 neuroblastoma cases and discovered that ALT-positive tumors have unique molecular characteristics, including lower ATRX/DAXX complex levels, mainly due to ATRX mutations or decreased protein expression.
- - Despite slower growth rates and a prolonged disease course, children with ALT-positive neuroblastomas experience poor prognoses, indicating a critical need for targeted clinical approaches.
Accurate modeling of intratumor heterogeneity presents a bottleneck against drug testing. Flexibility in a preclinical platform is also desirable to support assessment of different endpoints. We established the model system, OHC-NB1, from a bone marrow metastasis from a patient diagnosed with MYCN-amplified neuroblastoma and performed whole-exome sequencing on the source metastasis and the different models and passages during model development (monolayer cell line, 3D spheroid culture and subcutaneous xenograft tumors propagated in mice).
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- Folate is a vitamin that can help or hurt cells in our body, especially when looking at how it relates to cancer.
- Researchers studied how different levels of folate affected cells that were changed by the HPV virus, finding that low folate caused serious DNA damage and problems in how cells grow.
- The study suggests that not getting enough folate and then having too much can lead to cells becoming abnormal, which might increase the risk of cancer, so it’s important to think about folate supplements in places where people are lacking this nutrient.
Common fragile sites (cFSs) represent parts of the normal chromosome structure susceptible to breakage under replication stress. Although only a small number of cFSs have been molecularly characterized, genomic damage of cFS genes appears to be critical for the development of various human diseases. In this study, we fine mapped the location of FRA14B and showed that the fragile region spans 765 kb at 14q23.
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