The brain is the most complex organ in the human body and, as such, its study entails great challenges (methodological, theoretical, etc.). Nonetheless, there is a remarkable amount of studies about the consequences of pathological conditions on its development and functioning.
View Article and Find Full Text PDFThe formulation of the entropic statistical theory and the related neo-Hookean model has been a major advance in the modeling of rubber-like materials, but the failure to explain some experimental observations such as the slope in Mooney plots resulted in hundreds of micromechanical and phenomenological models. The origin of the difficulties, the reason for the apparent need for the second invariant, and the reason for the relative success of models based on the Valanis-Landel decomposition have been recently explained. From that insight, a new micro-macro chain stretch connection using the stretch tensor (instead of the right Cauchy-Green deformation tensor) has been proposed and supported both theoretically and from experimental data.
View Article and Find Full Text PDFThe human brain is arguably the most complex "machine" to ever exist. Its detailed functioning is yet to be fully understood, let alone modelled. Neurological processes have logical signal-processing and biophysical aspects, and both affect the brain's structure, functioning and adaptation.
View Article and Find Full Text PDFBackground And Objectives: Glioblastoma multiforme (GBM) is one of the most aggressive cancers of the central nervous system. It is characterized by a high mitotic activity and an infiltrative ability of the glioma cells, neovascularization and necrosis. GBM evolution entails the continuous interplay between heterogeneous cell populations, chemotaxis, and physical cues through different scales.
View Article and Find Full Text PDFResearch on auxetic metamaterials is important due to their high performance against impact loadings and their usefulness in actuators, among other applications. These metamaterials offer a negative Poisson's ratio at the macro level. However, usual auxetic metamaterials face challenges in (1) grading the effect, (2) coupling and combining auxetic metamaterials with non-auxetic materials due to boundary compatibility, (3) obtaining the same auxetic behavior in all directions in the transverse plane, and (4) adapting the regular geometry to the component design boundary and shape.
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