Publications by authors named "L Santangelo"
Background: The gastrointestinal (GI) tract represents one of the main targets of typical hemolytic uremic syndrome (HUS) in children. In this observational study, we tried to establish (1) the main features of GI complications during STEC-HUS and (2) the relationship between Escherichia coli serotypes and Shiga toxin (Stx) variants with hepatopancreatic involvement.
Methods: A total of 79 STEC-HUS patients were admitted to our pediatric nephrology department between January 2012 and June 2021.
Introduction: Recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KTx) develops in 40% of patients, leading to graft loss in half of cases. Extracorporeal apheretic treatments, combined with immunosuppressive drugs, seem to be the most promising therapies, but at now limited reports are available, mainly in pediatric patients.
Objective: We aimed to assess the efficacy of immunoadsorption (IA) to treat recurrent FSGS in pediatric patients.
Background: The Neurological involvement is the most common extra-renal complication of Shiga toxin-producing E. coli-hemolytic uremic syndrome (HUS) or typical HUS. On brain magnetic resonance examination, main neurological signs encompass acute lesions of the basal ganglia and the white matter, which could usually regress after Eculizumab infusion.
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- The text discusses a long non-coding RNA (lncRNA) that is overexpressed in various epithelial cancers and linked to increased invasion and metastasis through a process called epithelial-to-mesenchymal transition (EMT).
- The study created a deletion mutant of this lncRNA, which eliminated the domain that binds to EZH2, effectively acting as a dominant negative to block the lncRNA's function.
- Results show that this mutant reduced cancer cell motility, invasiveness, and growth, suggesting a new RNA-based strategy to inhibit key processes in tumor progression.