Publications by authors named "L Sang"
The systematic identification and functional characterization of noncanonical translation products, such as novel peptides, will facilitate the understanding of the human genome and provide new insights into cell biology. Here, we constructed a high-coverage peptide sequencing reference library with 11,668,944 open reading frames and employed an ultrafiltration tandem mass spectrometry assay to identify novel peptides. Through these methods, we discovered 8945 previously unannotated peptides from normal gastric tissues, gastric cancer tissues and cell lines, nearly half of which were derived from noncoding RNAs.
View Article and Find Full Text PDFBromodomain-containing protein 4 (BRD4) plays an important role in gene transcription in a variety of diseases, including inflammation and cancer. However, the mechanism by which the BRD4 inhibitors bind selectively to its bromodomain 1 (BRD4-BD1) and bromodomain 2 (BRD4-BD2) remains unclear. Studying the interaction mechanism between bromodomain of BRD4 and inhibitors will provide new ideas for drug development and disease treatment.
View Article and Find Full Text PDFPurpose: The objective of this study is to elucidate the sensitizing effect of mesoporous silica nanoparticles (MSNs) on shear wave elastography (SWE) and to investigate the potential application of MSNs as a sensitizer to enhance the sensitivity of SWE in the diagnosis of metabolic-associated steatohepatitis (MASH).
Materials And Methods: The in vitro gelatin models with varying ratios were assessed using SWE to identify the gelatin ratio that most closely approximates with human liver stiffness. Following the characterization of the dispersion properties of MSNs, in vitro models incorporating MSNs of different particle sizes were developed.
Article Synopsis
- Chronic pain is common and poses a significant health challenge, with a gap in effective outpatient treatment options; internet hospitals in China have started to address this issue, but their effectiveness has not been thoroughly studied.
- The study aims to evaluate the effectiveness of chronic pain management through internet hospitals compared to traditional physical hospital visits, using a retrospective cohort approach.
- After analyzing data from 122 internet hospital patients and 739 physical hospital patients, with a final matched sample of 77 from each group, researchers found no significant difference in quality of life between the two treatment methods, indicating that internet hospitals may provide comparable care.
Background: The effects of early sport specialization on professional athletes' resilience in handling increased workloads and athletic success have not been fully described.
Hypothesis: National Basketball Association (NBA) players who were multisport athletes during high school would be able to withstand higher workloads with lower injury rates and have more athletic success compared with their single-sport peers.
Study Design: Descriptive epidemiology study.