Publications by authors named "L Sandrini"
Article Synopsis
- Identifying how radioresistance works in rhabdomyosarcoma (RMS), a type of pediatric tumor, is crucial for better treatment strategies.
- Researchers observed that radiation therapy increases the activity of key proteins (Akt1, Src, Cav1) that help cells resist damage and survive.
- Using cholesterol-lowering drugs (statins) can enhance cell death in RMS by boosting oxidative stress, which could improve the effectiveness of radiotherapy when combined with certain treatments.
There is a complex interrelationship between the nervous system and the cardiovascular system. Comorbidities of cardiovascular diseases (CVD) with mental disorders, and vice versa, are prevalent. Adults with mental disorders such as anxiety and depression have a higher risk of developing CVD, and people with CVD have an increased risk of being diagnosed with mental disorders.
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- Takotsubo cardiomyopathy (TTS) is shown to have long-term effects on the hemostatic system, with patients exhibiting accelerated clot formation and higher levels of platelet activation even years after the initial event.
- In a study of women with TTS, results indicated significant differences in clotting parameters compared to both healthy controls and those with coronary artery disease (CAD), pointing to unique pathophysiological changes in TTS.
- Findings suggest that the persistent alterations in the hemostatic system in TTS patients may contribute to recurrent events, highlighting the need for tailored antiplatelet therapy to mitigate adverse outcomes.
Background: Obesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs.
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