Publications by authors named "L Sandhow"
The central role of the endothelial microenvironment in orchestrating bone marrow (BM) homeostasis and hematopoietic support has been confirmed at various developmental stages and in adult life. The BM vasculature is crucial in mediating communication between BM parenchyma and circulating blood, displaying remarkable heterogeneity in structure and function. While vascular cell diversity in other tissues has long been recognized, the molecular basis of this phenomenon in BM is just now emerging.
View Article and Find Full Text PDFLeukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model.
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- Tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML) but do not eliminate leukemia-initiating stem cells (LSCs), leading to persistent disease and relapse.
- The study investigates bone marrow (BM) niches in CML patients and finds differences in niche composition and function, revealing that mesenchymal stem cells from CML patients better support both normal and CML cells.
- CXCL14 was identified as a key factor, as its loss in CML BM niches was linked to maintaining LSCs; restoring CXCL14 showed potential in inhibiting LSC growth and improving responses to TKIs like imatinib.
Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes during leukemia development and are controlled by the bone marrow (BM) niche. Extracellular matrix proteins, including laminin, are important BM niche components. However, their role in hematopoiesis regeneration and leukemia is unknown.
View Article and Find Full Text PDFThe deoxycytidine analogue cytarabine (ara-C) remains the backbone treatment of acute myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but must be combined with other chemotherapeutics to achieve cure. Yet, the underlying mechanism dictating synergistic efficacy of combination chemotherapy remains largely unknown. The dNTPase SAMHD1, which regulates dNTP homoeostasis antagonistically to ribonucleotide reductase (RNR), limits ara-C efficacy by hydrolysing the active triphosphate metabolite ara-CTP.
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