Publications by authors named "L Sanchez-Brea"
Acute retinal pigment epitheliitis using adaptive optics imaging: a case report.
BMC Ophthalmol
November 2024
Article Synopsis
- Acute Retinal Pigment Epitheliitis (ARPE) is a rare eye disorder mostly affecting young adults, leading to temporary vision loss, often resolving within 6 to 12 weeks.
- The condition was studied in two patients using advanced imaging techniques like Optical Coherence Tomography (OCT) and Adaptive Optics Flood Illumination Ophthalmoscopy (AO-FIO), revealing insights into retinal changes and recovery.
- Both patients showed initial vision loss but eventually regained eyesight, although some retinal structural changes persisted even after improvement, highlighting the disease's complex nature.
Purpose: To determine the thickness of the conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS-OCT).
Methods: We prospectively included 107 healthy individuals of different age groups (18-39 years, 40-54 years, 55-69 years and ≥70 years). For each eye, AS-OCT scans of four quadrants (temporal, nasal, superior and inferior) were acquired.
We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed.
View Article and Find Full Text PDFThe optic nerve head (ONH) represents the intraocular section of the optic nerve, which is prone to damage by intraocular pressure (IOP). The advent of optical coherence tomography (OCT) has enabled the evaluation of novel ONH parameters, namely the depth and curvature of the lamina cribrosa (LC). Together with the Bruch's membrane minimum-rim-width (BMO-MRW), these seem to be promising ONH parameters for diagnosis and monitoring of retinal diseases such as glaucoma.
View Article and Find Full Text PDFArticle Synopsis
- Retinal vascular diseases are a major cause of blindness, and adaptive optics (AO) imaging allows for high-resolution observation of retinal microstructures, revealing important vascular biomarkers.
- This systematic review analyzed 42 studies on retinal vascular biomarkers using AO techniques, focusing on those most frequently researched: inner diameter (ID), outer diameter (OD), parietal thickness (PT), wall cross-sectional area (WCSA), and wall-to-lumen ratio (WLR).
- The meta-analysis indicated significant differences in WLR, PT, and ID among hypertensive patients compared to healthy individuals, highlighting the need for further research and standardization to validate these biomarkers for monitoring diseases.