Publications by authors named "L Salvini"
Unraveling vulnerabilities in chronic lymphocytic leukemia (CLL) represents a key approach to understand molecular basis for its indolence and a path toward developing tailored therapeutic approaches. In this study, we found that CLL cells are particularly sensitive to the inhibitory action of abundant serum protein, apolipoprotein E (ApoE). Physiological concentrations of ApoE affect CLL cell viability and inhibit CD40-driven proliferation.
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- Repurposing saffron waste offers a sustainable way to create valuable products, as discarding flower components results in a large amount of waste—350 kg of tepals for every kg of stigmas.
- This research utilized bioactivity studies and Life Cycle Assessments to analyze the beneficial compounds found in saffron tepals from Tuscany, discovering various flavonoids and their ability to reduce oxidative stress and enhance fermentation processes in yeast.
- The findings also indicated significant anti-inflammatory properties and potential applications in pharmaceuticals and cosmetics, while highlighting the environmental benefits of such a "green" approach in supporting the circular bioeconomy.
Glycoconjugation is a well-established technology for vaccine development: linkage of the polysaccharide (PS) antigen to an appropriate carrier protein overcomes the limitations of PS T-independent antigens, making them effective in infants and providing immunological memory. Glycoconjugate vaccines have been successful in reducing the burden of different diseases globally. However, many pathogens still require a vaccine, and many of them display a variety of glycans on their surface that have been proposed as key antigens for the development of high-valency glycoconjugate vaccines.
View Article and Find Full Text PDFThe concept of a "circular bioeconomy" holds great promise for the health, cosmetic, and nutrition sectors by re-using (Mill.) by-products. This sustainable resource is rich in bioactive secondary metabolites with antioxidant and anti-inflammatory properties.
View Article and Find Full Text PDFUtilizing plant-based resources, particularly their by-products, aligns with sustainability principles and circular bioeconomy, contributing to environmental preservation. The therapeutic potential of plant extracts is garnering increasing interest, and this study aimed to demonstrate promising outcomes from an extract obtained from an underutilized plant waste. , an invasive macroalga found in the Orbetello Lagoon, thrives in eutrophic conditions, forming persistent mats covering approximately 400 hectares since 2005.
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