DTMP-prime: A deep transformer-based model for predicting prime editing efficiency and PegRNA activity.

Prime editors are CRISPR-based genome engineering tools with significant potential for rectifying patient mutations. However, their usage requires experimental optimization of the prime editing guide RNA (PegRNA) to achieve high editing efficiency. This paper introduces the deep transformer-based model for predicting prime editing efficiency (DTMP-Prime), a tool specifically designed to predict PegRNA activity and prime editing (PE) efficiency.

StructmRNA a BERT based model with dual level and conditional masking for mRNA representation.

In this study, we introduce StructmRNA, a new BERT-based model that was designed for the detailed analysis of mRNA sequences and structures. The success of DNABERT in understanding the intricate language of non-coding DNA with bidirectional encoder representations is extended to mRNA with StructmRNA. This new model uses a special dual-level masking technique that covers both sequence and structure, along with conditional masking.

Prevalence of blood stream infections and associated factors among febrile neutropenic cancer patients on chemotherapy at Ocean Road Cancer Institute, Tanzania.

Background: Febrile Neutropenia (FN) caused by bacteria in cancer patients is associated with poor prognosis. The aim of this study was to determine the prevalence of FN and associated factors among cancer patients on chemotherapy at Ocean Road Cancer Institute (ORCI), Tanzania.

Methods: A cross-sectional study was conducted from June to September 2019.

Making Advance Care Planning a part of cancer patients' end-of-life care in Rwanda.

After the devastating damage inflicted by the 1994 Genocide against the Tutsi, Rwanda made great strides in reconstructing its healthcare system from scratch. Although cancer mortality rates continue to rise, there is still a dearth of qualified healthcare workers for advance care planning (ACP) for terminally ill patients. I will draw on lessons learned through the literature search for the initiation of ACP and reflect on their adaptation to the existing policies, healthcare systems, and workforce in Rwanda.

A Survey on Current-Mode Interfaces for Bio Signals and Sensors.

In this study, a review of second-generation voltage conveyor (VCII) and current conveyor (CCII) circuits for the conditioning of bio signals and sensors is presented. The CCII is the most known current-mode active block, able to overcome some of the limitations of the classical operational amplifier, which provides an output current instead of a voltage. The VCII is nothing more than the dual of the CCII, and for this reason it enjoys almost all the properties of the CCII but also provides an easy-to-read voltage as an output signal.