Publications by authors named "L Saari"
Article Synopsis
- - Pseudoxanthoma elasticum (PXE) is a rare genetic disorder that leads to issues like retinal problems, skin changes, and hardened arteries, primarily due to calcification beneath the retina, which can cause macular degeneration.
- - Researchers created and studied two specific induced pluripotent stem cell (hiPSC) lines from a PXE patient, focusing on retinal pigment epithelial (RPE) cells to compare their features with those of healthy cells.
- - Initial findings showed that PXE-specific RPE cells have increased pigmentation and poorer barrier and phagocytic functions compared to healthy controls, suggesting factors that contribute to macular degeneration in PXE patients, with further validation needed in more patients.
Background: The dopaminergic system modulates growth hormone secretion and previous results have suggested a link between short stature and an increased risk of Parkinson's disease (PD).
Methods: In 36 Lewy body spectrum disease (LBD) cases (PD = 22) and 19 controls, nigral TH-positive neuron densities were measured postmortem from midbrain sections and corrected with the Abercrombie method. Body measurements were collected from autopsies or patient records.
Parkinson's disease and other Lewy body spectrum diseases (LBDs) are associated with a specific risk for clinical depression. In the present clinicopathological study with 73 patients with LBD, we observed that the substantia nigra pars compacta dopamine neuron density was markedly lower in patients who had comorbid depression antemortem than in nondepressed patients (1.52 vs 2.
View Article and Find Full Text PDFContext.—: Preanalytic errors, including specimen labeling errors and specimen loss, occur frequently during specimen collection, transit, and accessioning. Radio-frequency identification tags can decrease specimen identification and tracking errors through continuous and automated tracking of specimens.
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