Publications by authors named "L S Zubarovskaya"
Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study.
Chantal Lucini Klára Obrová Isabella Krickl Filomena Nogueira Iva Kocmanová Ludmilla Zubarovskaya Natalia Zubarovskaya
J Hematol Oncol
August 2024
Article Synopsis
- * Antifungal prophylaxis has reduced IFD occurrences but has also changed the types of fungal pathogens seen, necessitating broader screening methods for early diagnosis and treatment.
- * A study analyzed blood samples from high-risk patients using advanced PCR techniques, revealing that many detectable fungi were typically non-pathogenic, highlighting the need for repeated testing and accurate identification to guide effective treatment.
Article Synopsis
- A pilot clinical study showed that oral microbiota transplantation from a healthy mother to her 6-month-old child with neuroblastoma can safely prevent chemotherapy-induced oral mucositis.
- The patient received oral donor saliva during chemotherapy cycles, which led to a significant reduction in the severity of oral mucositis, only experiencing mild symptoms after hematopoietic cell transplantation.
- The study also revealed changes in the patient's oral bacteria, with an increase in beneficial bacteria and a decrease in harmful strains, and no adverse effects from the transplantation were reported.
Matched unrelated donor transplantation versus haploidentical transplantation with post-transplant cyclophosphamide in children with acute myeloid leukemia: a PDWP-EBMT study.
Annalisa Ruggeri Nicole Santoro Jacques-Emmanuel Galimard Krzysztof Kalwak Mattia Algeri Ludmila Zubarovskaya
Haematologica
July 2024
Article Synopsis
- In kids with acute myeloid leukemia (AML) who don't have a sibling that is a perfect match for a donor, doctors can use other types of donors.
- This study looked at how well kids with AML did after receiving stem cell transplants from two different types of donors from 2011 to 2021.
- It found that while one type of transplant (from a haploidentical donor) had a higher risk of certain complications, both transplant types showed similar success rates in keeping the leukemia away and overall survival after two years.
Post-transplant сyclophosphamide after matched donor hematopoietic stem cell transplantation in children with acute leukemia.
Anastasya Svyatoslavovna Borovkova Olesya Vladimirovna Paina Elena Vladimirovna Semenova Tatiana Alexandrovna Bykova Anna Alekseevna Osipova Ludmila Stepanovna Zubarovskaya
Clin Transplant
January 2024
Article Synopsis
- - The study investigates the effectiveness of post-transplant cyclophosphamide (PTCy) in preventing graft-versus-host disease (GVHD) in pediatric acute leukemia patients who underwent matched allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- - A retrospective analysis of 190 children shows that PTCy-based GVHD prophylaxis led to significantly lower rates of acute and chronic GVHD after transplants from matched unrelated donors (MUD) compared to standard treatments.
- - The findings suggest PTCy is a promising and effective option for GVHD prevention in pediatric patients, particularly in MUD settings, while showing similar efficacy to traditional methods in matched sibling donor (MSD) transplants. *
Article Synopsis
- This analysis reviewed trends in 5185 hematopoietic cell transplantations (HCT) between 1990 and 2022, including 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) transplants.
- There was a significant improvement in event-free survival (EFS) for both autoHCT and alloHCT over time, attributed to a decrease in relapse rates and non-relapse mortality, respectively.
- Specific survival improvements were noted for various conditions, with autoHCT showing better outcomes in Hodgkin's disease and multiple myeloma, while alloHCT advancements were observed mainly in leukemia and lymphomas.