Radiation-Induced Tumor-Derived Extracellular Vesicles Combined with Tyrosine Kinase Inhibitors: An Effective and Safe Therapeutic Approach for Lung Adenocarcinoma with EGFR19Del.

Combining radiotherapy with targeted therapy benefits patients with advanced epidermal growth factor receptor-mutated non-small cell lung cancer (EGFRm NSCLC). However, the optimal strategy to combine EGFR tyrosine kinase inhibitors (TKIs) with radiotherapy for maximum efficacy and minimal toxicity is still uncertain. Notably, EVs, which serve as communication mediators among tumor cells, play a crucial role in the anti-tumor immune response.

Research on Tool Wear Monitoring Technology Based on Variational Mode Decomposition and Back Propagation Neural Network Model.

Accurately predicting tool wear during the machining process not only saves machining time and improves efficiency but also ensures the production of good-quality parts and automation. This paper proposes a combined variational mode decomposition (VMD) and back propagation (BP) neural network model (VMD-BP), which maps spindle power to tool wear. The model is trained using both historical and real-time data.

Genome-Wide Identification and Expression Analysis of the G-Protein Gene Family in Barley Under Abiotic Stresses.

Heterotrimeric G-proteins are fundamental signal transducers highly conserved in plant species, which play crucial roles in regulating plant growth, development, and responses to abiotic stresses. Identification of G-protein members and their expression patterns in plants are essential for improving crop resilience against environmental stresses. Here, we identified eight heterotrimeric G-protein genes localized on four chromosomes within the barley genome by using comprehensive genome-wide analysis.

Effects of the Application of DY1-3 on the Growth of Maize Plants and the Structure of Soil Bacterial Community.

Against the background of increasing salinisation of land, the use of environmentally friendly plant growth-promoting bacteria (PGPB) resources for soil improvement is particularly important. The aim of this study was to investigate the effects of DY1-3 on maize seedling growth, soil physico-chemical properties, and bacterial community structure. The study also evaluates the effects of this microbial agent on plant growth and saline soil improvement, providing theoretical references for microbial agents in promoting plant growth and improving saline soils.

Laser Fabrication and Performance of Flexible Pressure Sensors with Ridge-Mimicking Spatially Ordered Microstructures.

The proliferation of flexible pressure sensors has generated new demands for high-sensitivity and low-cost sensors. Here, we propose an elegant strategy to address this challenge by taking a ridge-mimicking, gradient-varying, spatially ordered microstructure as the sensing layer, with laser processing and interdigitated electrodes as the upper and lower electrode layers. Simultaneously, the entire structure is encapsulated with polyimide (PI) tape for protection, and the fabrication process is relatively feasible, facilitating easy scaling.