Publications by authors named "L S Stiel"

Background: Activation of innate immunity is a first line of host defense during acute critical illness (ACI) that aims to contain injury and avoid tissue damages. Aberrant activation of innate immunity may also participate in the occurrence of organ failures during critical illness. This review aims to provide a narrative overview of recent advances in the field of innate immunity in critical illness, and to consider future potential therapeutic strategies.

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Background: Hyperglycaemia is common in critically ill patients, but blood glucose and insulin management may differ widely among intensive care units (ICUs). We aimed to describe insulin use practices and the resulting glycaemic control in French ICUs. We conducted a multicentre 1-day observational study on November 23, 2021, in 69 French ICUs.

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Purpose: Cardiac surgery with cardiopulmonary bypass triggers sterile inflammation that is responsible for post-operative morbidity. Automated flow cytometry devices used for leucocyte count provide cell population data (CPD) regarding fluorescence intensity, size and granularity of leukocytes that have never been studied in the context of sterile inflammation. Our objective was to explore leukocyte cell population data in patients undergoing cardiac surgery with cardiopulmonary bypass in order to determine whether CPD could be used to monitor immune cell activation.

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Article Synopsis
  • Post-intensive care syndrome (PICS) is a condition that causes lasting physical, cognitive, and mental impairments after leaving the ICU, significantly affecting patients' long-term health and quality of life.
  • The review discusses key issues related to PICS, including muscle weakness, cognitive deficits associated with delirium, and long-term effects on the immune system, kidneys, and lungs.
  • Understanding the biological processes underlying PICS can lead to improved patient care and new strategies for prevention and treatment.
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