Publications by authors named "L S Sokurenko"
Objective: The aim: To assess the structural and metabolic changes in the sensorimotor cortex of the rat brain under conditions of hemorrhagic stroke.
Patients And Methods: Materials and methods: The experiment was carried out on rats of the control and experimental groups with a model of hemorrhagic stroke. We used histological, electron microscopic, biochemical methods and biological markers.
Objective: The aim: To study the association between A/A, G/A, A/A genotypes, alleles A, G of the SNP rs17216473 of the gene that encodes ALOX5AP and the risk of myocardial infarction within the Ukrainian population.
Patients And Methods: Materials and methods: PCR in real time and the analysis to discriminate alleles were used. The statistical processing was carried out by χ2 criteria and by χ2 criteria with Yates correction.
Objective: The aim: Studying changes in the ultrastructure of blood circulatory capillaries of the myocardium of mature rats with hypothyroidism and arterial hypertension.
Patients And Methods: Materials and methods: Experiments were conducted on (240 days) 10 ISIAH (inherited stress-induced arterial hypertension) line rats with AH (arterial hypertension), 10 Wistar line rats with congenital hypothyroidism and 10 intact animals. Arterial pressure was measured, and the development of hypothyroidism was controlled by the immune enzyme method.
Objective: The aim: Was to compare the changes in hematological parameters of blood in the conditions of prolonged exposure of lead sulfide nanoparticles (NP) of different sizes and of lead nitrate.
Patients And Methods: Materials and methods: The study was conducted on mature male Wistar rats 160-180 g, intraperitoneally injected with Pb(NO3)2 and NP PbS of 26-34 nm and 50-80 nm in 0,94 mg/kg/day dose adjusted to lead. Toxic effects were evaluated after 1,5 months, 3 months and 1 month after exposure.
Objective: The aim: Study of the patterns of structural changes in the left ventricular myocardial capillaries of rats with arterial hypertension with combined pharmacotherapy with Bisoprolol and Thiotriazolinum.
Patients And Methods: Materials and methods: Experiments were conducted on 30 line rats with congenital stress-induced arterial hypertension: 10 animals without treatment and 10 animals with treatment. Pharmacological correction of spontaneous arterial hypertension was performed with 20 mg / kg of Bisoprolol and 50 mg / kg of Thiotriazolinum per os once a day.