CLINICAL AND GENETIC PREDICTORS AND PROGNOSTIC MODEL OF RAPIDLY PROGRESSIVE HEPATIC FIBROSIS IN CHRONIC HEPATITIS C.

The search for risk factors for rapid progression of hepatic fibrosis (HF) in chronic hepatitis C (CHC) is a topical scientific and practical task. The purpose of the study is to identify clinical and genetic predictors and create the prognostic model of rapidly progressive HF in CHC. A retrospective cohort study of 125 patients with CHC has been carried out.

Imaging Methods of Joint Damage in Early Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is an autoimmune connective tissue disease of unknown etiology with development of persistent and erosive arthritis ultimately resulting in disability. The prevalence of RA is about 0.5-1% in adults worldwide.

Diagnostic value of antibodies to modified citrullinated vimentin in early rheumatoid arthritis.

The aim of this study was to evaluate the usefulness of antibodies to modified citrullinated vimentin (anti-MCV) for diagnosing early rheumatoid arthritis (RA) and to examine the correlations between anti-MCV and clinical parameters as well as radiographic and ultrasound data. Our results suggest that anti-MCV has a sensitivity and specificity of 53.3 and 83.

Treatment of early arthritis using arthrofoon (ultra-low doses of antibodies to tumor necrosis factor-α).

The main aim of treatment of early rheumatoid arthritis (RA) should be to achieve clinical remission to prevent structural damage and physical disability. Arthrofoon modifies production/activity of endogenous inhibitors of tumor necrosis factor-α (TNF-α). The sublingual rout is the most acceptable to ambulatory treatment because it does not produce the adverse reactions associated with intravenous therapy.

[Comparative analysis of effectiveness and safety of diclofenac and nimesulide in patients with early rheumatoid arthritis].

The aim of the work was to evaluate effectiveness and safety of diclofenac and nimesulide in patients with early RA. The open clinical study included 80 outpatients (mean age 49.0 +/- 11.