Human gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.

The human Lymphocyte antigen-6 () gene family has recently gained interest for its possible role in tumor progression. We have carried out analyses of all known gene expression and amplification in different cancers using TNMplot and cBioportal. We also have analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database.

The Effect of Climate Change on Food Crop Production in Lagos State.

Climate change is set to be particularly disruptive in poor agricultural communities. This study examines the effects of, and farmer's perceptions of, climate change on farming practices for cassava and maize in Lagos, Nigeria. Analysis of weather data from 1998 to 2018 (the most recent available) reveals little impact on cassava yield but a significant impact on maize yield.

Emerging Cnidarian Models for the Study of Epithelial Polarity.

Epithelial tissues are vital to the function of most organs, providing critical functions such as secretion, protection, and absorption. Cells within an epithelial layer must coordinate to create functionally distinct apical, lateral, and basal surfaces in order to maintain proper organ function and organism viability. This is accomplished through the careful targeting of polarity factors to their respective locations within the cell, as well as the strategic placement of post-mitotic cells within the epithelium during tissue morphogenesis.

Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo.

The last stage of cell division involves two daughter cells remaining interconnected by a cytokinetic bridge that is cleaved during abscission. Conserved between the zebrafish embryo and human cells, we found that the oldest centrosome moves in a Rab11-dependent manner towards the cytokinetic bridge sometimes followed by the youngest. Rab11-endosomes are organized in a Rab11-GTP dependent manner at the mother centriole during pre-abscission, with Rab11 endosomes at the oldest centrosome being more mobile compared with the youngest.

Imaging the early zebrafish embryo centrosomes following injection of small-molecule inhibitors to understand spindle formation.

During the earliest division stages, zebrafish embryos have large cells that divide rapidly and synchronously to create a cellular layer on top of the yolk. Here, we describe a protocol for monitoring spindle dynamics during these early embryonic divisions. We outline techniques for injecting zebrafish embryos with small-molecule inhibitors toward polo-like kinases, preparing and mounting embryos for three-dimensional imaging using confocal microscopy.