Publications by authors named "L S Mortensen"
Objective: Studies of squamous cell carcinoma of the head and neck (HNSCC) have demonstrated the importance of nuclear receptors and their associated coregulators in the development and treatment of HNSCC. We sought to characterize members of the nuclear receptor super family through interrogation of RNA-Seq and microarray data.
Materials And Methods: TCGA RNA-Seq data within the cBioportal platform comparing HNSCC samples (n = 515 patients with RNA-Seq data) to normal tissue (n = 82 patients) was interrogated for significant differences in nuclear receptor expression.
Polarization-resolved second harmonic generation (pSHG) is a label-free method that has been used in a range of tissue types to describe collagen orientation. In this work, we develop pSHG analysis techniques for investigating cranial bone collagen assembly defects occurring in a mouse model of hypophosphatasia (HPP), a metabolic bone disease characterized by a lack of bone mineralization. After observing differences in bone collagen lamellar sheet structures using scanning electron microscopy, we found similar alterations with pSHG between the healthy and HPP mouse collagen lamellar sheet organization.
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- The study investigates the link between residential greenspace and the impact of COVID-19 on health, focusing on Danish adults 50 and older during the pandemic.* -
- Researchers found that increased greenspace was associated with lower rates of COVID-19 infection, hospitalization, and mortality, especially among vulnerable groups like the elderly and those with chronic illnesses.* -
- Health impact assessments suggested that enhancing local greenspace could have potentially prevented 8-14% of COVID-19 cases in the population studied, indicating benefits of greening initiatives.*
Introduction: The COVID-19 pandemic overwhelmed health systems, resulting in a surge in excess deaths. This study clustered countries based on excess mortality to understand their response to the pandemic and the influence of various factors on excess mortality within each cluster.
Materials And Methods: This ecological study is part of the COVID-19 MORtality (C-MOR) Consortium.
Article Synopsis
- Out-of-hospital cardiac arrest is a major global health issue, necessitating effective vascular access for drug administration during resuscitation.
- A clinical trial comparing intraosseous and intravenous methods found that both had similar effectiveness for restoring circulation, with around 30% of patients in each group succeeding.
- At 30 days post-arrest, survival rates and favorable neurologic outcomes also showed no significant differences between the two methods, indicating both approaches are equally viable.