Clinical and Pathologic Characteristics of Cytologically Indeterminate Thyroid Nodules with Non-V600E Alterations.

Background: Molecular assays serve as a potential risk stratification tool for cytologically indeterminate thyroid nodules (ITNs). mutations are nearly always associated with thyroid cancer. However, the malignancy risk for ITNs with other less common alterations is less well understood.

Effects of the KCNQ (Kv7) Channel Opener Ezogabine on Resting-State Functional Connectivity of Striatal Brain Reward Regions, Depression and Anhedonia in Major Depressive Disorder: Results from a Randomized Controlled Trial.

Background: Major depressive disorder (MDD) is a leading cause of disability worldwide, with available treatments often showing limited efficacy. Recent research suggests targeting specific subtypes of depression and understanding the underlying brain mechanisms can improve treatment outcomes. This study investigates the potential of the potassium KCNQ (Kv7) channel opener ezogabine to modulate the resting-state functional connectivity (RSFC) of the brain's reward circuitry and alleviate depressive symptoms, including anhedonia, a core feature of MDD.

Tips for quality publishing; lessons from the neuroscience editorial team.

In pursuit of excellence in scholarly publishing, the Neuroscience editorial team shares valuable insights that are essential for authors, reviewers, and the broader scientific community. Firstly, we emphasize that impactful research is built on rigorous study design and execution. Beyond fundamental methodological safeguards such as randomization and blinded analysis, we highlight the importance of thoughtfully selecting study models, with deliberate attention to biological variables like sex and gender, as well as appropriate nomenclature.

A photo-narrative intervention protocol for clinicians and parents of children with severe neurological impairment in the PICU.

Background: Children with severe neurological impairment (SNI) have central nervous system conditions that result in medical complexity and lifelong caregiver assistance. When children with SNI are admitted to the pediatric intensive care unit (PICU), their parents/families may experience elevated stress due to poor communication with clinicians.

Methods: To address this, we created a photo-narrative intervention designed to facilitate parent-clinician communication.

Promoting π-Facial Interactions in Phenyl-Substituted 1,8-Bis(silylamido)naphthalene Alkaline Earth Complexes.

Bimetallic 1,8-bis(silylamido)naphthalene alkaline earth complexes [( L)Ae] ([ L] = [1,8-{(RSi)N}CH)], where R = PhMe, Ae = Ca (), Sr (), and Ba (); R = Ph, Ae = Ca (), Sr (), and Ba () were prepared protonolysis reactions of the phenyl-substituted proligands LH and LH with [AeN″] (N″ = [N(SiMe)]) in benzene. X-ray crystallographic analysis showed that , , and crystallize as nitrogen-bridged dimers. Conversely, and display a naphthalene-bridged motif, while the structure of is intermediate between the two distinct classes.